Submissions from biorxiv.org

• Sarbecovirus comparative genomics elucidates gene content of SARS-CoV-2 and functional impact of COVID-19 pandemic mutations

  (biorxiv.org)

  Published on 4th Jun 2020
• An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

  (biorxiv.org)

  Published on 3rd Jun 2020
• Pathogenesis, transmission and response to re-exposure of SARS-CoV-2 in domestic cats

  (biorxiv.org)

  Published on 2nd Jun 2020
• Minimal system for assembly of SARS-CoV-2 virus like particles

  (biorxiv.org)

  Published on 2nd Jun 2020
• coronapp: a Web Application to Annotate and Monitor SARS-CoV-2 Mutations

  (biorxiv.org)

  Published on 2nd Jun 2020
• Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

  (biorxiv.org)

  Published on 1st Jun 2020
• Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

  (biorxiv.org)

  Published on 28th May 2020
• Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals

  (biorxiv.org)

  Published on 28th May 2020
• The emergence of SARS-CoV-2 in Europe and the US

  (biorxiv.org)

  Published on 27th May 2020
• T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysis

  (biorxiv.org)

  Published on 27th May 2020
• SARS-CoV-2 genome evolution exposes early human adaptations

  (biorxiv.org)

  Published on 27th May 2020
• The Red Queen’s Crown: an evolutionary arms race between coronaviruses and mammalian species reflected in positive selection of the ACE2 receptor among many species

  (biorxiv.org)

  Published on 26th May 2020
• Mass Spectrometric detection of SARS-CoV-2 virus in scrapings of the epithelium of the nasopharynx of infected patients via Nucleocapsid N protein

  (biorxiv.org)

  Published on 26th May 2020
• Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

  (biorxiv.org)

  Published on 25th May 2020
• The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

  (biorxiv.org)

  Published on 25th May 2020
• Structural basis of SARS-CoV-2 spike protein induced by ACE2

  (biorxiv.org)

  Published on 25th May 2020
• Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

  (biorxiv.org)

  Published on 25th May 2020
• An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations

  (biorxiv.org)

  Published on 24th May 2020
• Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

  (biorxiv.org)

  Published on 24th May 2020
• Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

  (biorxiv.org)

  Published on 24th May 2020
• Lung epithelial stem cells express SARS-CoV-2 entry factors: implications for COVID-19

  (biorxiv.org)

  Published on 24th May 2020
• A previously uncharacterized gene in SARS-CoV-2 illuminates the functional dynamics and evolutionary origins of the COVID-19 pandemic

  (biorxiv.org)

  Published on 24th May 2020
• Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19

  (biorxiv.org)

  Published on 24th May 2020
• Unfractionated heparin potently inhibits the binding of SARS-CoV-2 spike protein to a human cell line

  (biorxiv.org)

  Published on 22nd May 2020
• SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

  (biorxiv.org)

  Published on 22nd May 2020
• No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2

  (biorxiv.org)

  Published on 22nd May 2020
• The impact of super-spreaders in COVID-19: mapping genome variation worldwide

  (biorxiv.org)

  Published on 20th May 2020
• Antiviral activity of Glucosylceramide synthase inhibitors against SARS-CoV-2 and other RNA virus infections

  (biorxiv.org)

  Published on 20th May 2020
• Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model

  (biorxiv.org)

  Published on 20th May 2020
• SARS-CoV2 infection in farmed mink in Netherlands

  (biorxiv.org)

  Published on 19th May 2020
• Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

  (biorxiv.org)

  Published on 19th May 2020
• Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes

  (biorxiv.org)

  Published on 18th May 2020
• Establishment of an African green monkey model for COVID-19

  (biorxiv.org)

  Published on 18th May 2020
• Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

  (biorxiv.org)

  Published on 18th May 2020
• SARS-CoV-2 is well adapted for humans. Lab origin can’t be ruled out

  (biorxiv.org)

  Published on 18th May 2020
• SARS-CoV-2 is well adapted for humans. What does this mean for re-emergence?

  (biorxiv.org)

  Published on 17th May 2020
• Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2

  (biorxiv.org)

  Published on 17th May 2020
• Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

  (biorxiv.org)

  Published on 17th May 2020
• Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement

  (biorxiv.org)

  Published on 17th May 2020
• ACE2-Variants Indicate Potential SARS-CoV-2-Susceptibility in Animals: An Extensive Molecular Dynamics Study

  (biorxiv.org)

  Published on 15th May 2020
• The Red Queen's Crown: an evolutionary arms race between coronaviruses and mammalian species reflected in positive selection of the ACE2 receptor among many species

  (biorxiv.org)

  Published on 15th May 2020
• Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation

  (biorxiv.org)

  Published on 15th May 2020
• Potent neutralization of SARS-CoV-2 in vitro and in an animal model by a human monoclonal antibody

  (biorxiv.org)

  Published on 15th May 2020
• ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

  (biorxiv.org)

  Published on 15th May 2020
• SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant

  (biorxiv.org)

  Published on 13th May 2020
• Controlling the SARS-CoV-2 outbreak, insights from large scale whole genome sequences generated across the world

  (biorxiv.org)

  Published on 12th May 2020
• Clinical performance of SARS-CoV-2 IgG antibody tests and potential protective immunity

  (biorxiv.org)

  Published on 11th May 2020
• Cholesterol and COVID19 lethality in elderly

  (biorxiv.org)

  Published on 11th May 2020
• A modified ACE2 peptide mimic to block SARS-CoV2 entry

  (biorxiv.org)

  Published on 10th May 2020
• Development of a COVID-19 vaccine based on the receptor binding domain displayed on virus-like particles

  (biorxiv.org)

  Published on 10th May 2020
• Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission

  (biorxiv.org)

  Published on 10th May 2020
• Identification of neutralizing human monoclonal antibodies from Italian Covid-19 convalescent patients

  (biorxiv.org)

  Published on 10th May 2020
• ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection

  (biorxiv.org)

  Published on 10th May 2020
• The SARS-CoV-2-like virus found in captive pangolins from Guangdong should be better sequenced.

  (biorxiv.org)

  Published on 10th May 2020
• Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of TMPRSS2 and MX1 Genes

  (biorxiv.org)

  Published on 6th May 2020
• Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19

  (biorxiv.org)

  Published on 5th May 2020
• Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

  (biorxiv.org)

  Published on 4th May 2020
• Heat inactivation of the Severe Acute Respiratory Syndrome Coronavirus 2

  (biorxiv.org)

  Published on 3rd May 2020
• Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients

  (biorxiv.org)

  Published on 3rd May 2020
• Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

  (biorxiv.org)

  Published on 1st May 2020
• Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

  (biorxiv.org)

  Published on 1st May 2020
• An engineered stable mini-protein to plug SARS-Cov2 Spikes

  (biorxiv.org)

  Published on 30th Apr 2020
• Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

  (biorxiv.org)

  Published on 28th Apr 2020
• Structure of replicating SARS-CoV-2 polymerase

  (biorxiv.org)

  Published on 28th Apr 2020
• Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics

  (biorxiv.org)

  Published on 28th Apr 2020
• A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains

  (biorxiv.org)

  Published on 28th Apr 2020
• Comparison of commercial RT-PCR diagnostic kits for COVID-19

  (biorxiv.org)

  Published on 26th Apr 2020
• Donut PCR: a rapid, portable, multiplexed, and quantitative DNA detection platform with single-nucleotide specificity

  (biorxiv.org)

  Published on 26th Apr 2020
• Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients

  (biorxiv.org)

  Published on 26th Apr 2020
• STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

  (biorxiv.org)

  Published on 24th Apr 2020
• Programmable low-cost DNA-based platform for viral RNA detection

  (biorxiv.org)

  Published on 24th Apr 2020
• Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

  (biorxiv.org)

  Published on 24th Apr 2020
• The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro: an existing drug with multiple possible therapeutic effects

  (biorxiv.org)

  Published on 23rd Apr 2020
• Cross-reactive neutralization of SARS-CoV-2 by serum antibodies from recovered SARS patients and immunized animals

  (biorxiv.org)

  Published on 22nd Apr 2020