Submissions from biorxiv.org

• A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid: ssDNA fashioned to imitate structural constraints of the NPC provides insight into recent research unprecedentedly suggesting the HIV-1 core uncoats within the nucleus.

  (biorxiv.org)

  Published on 15th Oct 2020
• Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

  (biorxiv.org)

  Published on 12th Oct 2020
• The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

  (biorxiv.org)

  Published on 12th Oct 2020
• Extremely potent human monoclonal antibodies from convalescent Covid-19 patients

  (biorxiv.org)

  Published on 8th Oct 2020
• GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition

  (biorxiv.org)

  Published on 7th Oct 2020
• Transcriptional differences for COVID-19 Disease Map genes between males and females indicate a different basal immunophenotype relevant to the disease

  (biorxiv.org)

  Published on 2nd Oct 2020
• SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro

  (biorxiv.org)

  Published on 2nd Oct 2020
• LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

  (biorxiv.org)

  Published on 2nd Oct 2020
• S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

  (biorxiv.org)

  Published on 25th Sep 2020
• Respiratory disease in cats associated with human-to-cat transmission of SARS-CoV-2 in the UK

  (biorxiv.org)

  Published on 24th Sep 2020
• The Anti-histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits SARS-CoV-2 Infection in Reconstituted Human Nasal Tissue In Vitro

  (biorxiv.org)

  Published on 21st Sep 2020
• Topography, spike dynamics and nanomechanics of individual native SARS-CoV-2 virions

  (biorxiv.org)

  Published on 21st Sep 2020
• Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

  (biorxiv.org)

  Published on 18th Sep 2020
• Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2.

  (biorxiv.org)

  Published on 15th Sep 2020
• No evidence of coronaviruses or other potentially zoonotic viruses in Sunda pangolins (Manis javanica) entering the wildlife trade via Malaysia

  (biorxiv.org)

  Published on 15th Sep 2020
• Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model

  (biorxiv.org)

  Published on 13th Sep 2020
• Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

  (biorxiv.org)

  Published on 13th Sep 2020
• A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

  (biorxiv.org)

  Published on 9th Sep 2020
• Long-term survival of salmon-attached SARS-CoV-2 at 4 degree as a potential source of transmission in seafood markets

  (biorxiv.org)

  Published on 7th Sep 2020
• Versatile, Multivalent Nanobody Cocktails for Highly Efficient SARS-CoV-2 Neutralization

  (biorxiv.org)

  Published on 28th Aug 2020
• Susceptibility of rabbits to SARS-CoV-2

  (biorxiv.org)

  Published on 28th Aug 2020
• An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

  (biorxiv.org)

  Published on 21st Aug 2020
• SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons by Targeting Multiple Components of RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING Signaling Pathways

  (biorxiv.org)

  Published on 20th Aug 2020
• Equine hyperimmune globulin raised against the SARS-CoV-2 spike glycoprotein has extremely high neutralizing titers

  (biorxiv.org)

  Published on 20th Aug 2020
• Peptide Antidotes to SARS-CoV-2 (COVID-19)

  (biorxiv.org)

  Published on 18th Aug 2020
• A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

  (biorxiv.org)

  Published on 17th Aug 2020
• An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation

  (biorxiv.org)

  Published on 11th Aug 2020
• Peptide Antidotes to SARS-CoV-2 (COVID-19)

  (biorxiv.org)

  Published on 9th Aug 2020
• De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

  (biorxiv.org)

  Published on 6th Aug 2020
• Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

  (biorxiv.org)

  Published on 6th Aug 2020
• Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19

  (biorxiv.org)

  Published on 6th Aug 2020
• Host metabolic reprogramming in response to SARS-Cov-2 infection

  (biorxiv.org)

  Published on 6th Aug 2020
• Infection of human lymphomononuclear cells by SARS-CoV-2

  (biorxiv.org)

  Published on 6th Aug 2020
• Cold-adapted live attenuated SARS-CoV-2 vaccine completely protects human ACE2 transgenic mice from SARS-CoV-2 infection

  (biorxiv.org)

  Published on 6th Aug 2020
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

  (biorxiv.org)

  Published on 3rd Aug 2020
• CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation

  (biorxiv.org)

  Published on 31st Jul 2020
• Respiratory bacteria stabilize and promote airborne transmission of influenza A virus

  (biorxiv.org)

  Published on 29th Jul 2020
• Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

  (biorxiv.org)

  Published on 24th Jul 2020
• Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

  (biorxiv.org)

  Published on 23rd Jul 2020
• Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

  (biorxiv.org)

  Published on 22nd Jul 2020
• SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

  (biorxiv.org)

  Published on 19th Jul 2020
• Interplay of Monocytes and T Lymphocytes in COVID-19 Severity

  (biorxiv.org)

  Published on 19th Jul 2020
• A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

  (biorxiv.org)

  Published on 17th Jul 2020
• Tafenoquine inhibits replication of SARS-Cov-2 at pharmacologically relevant concentrations in vitro

  (biorxiv.org)

  Published on 13th Jul 2020
• Genomic variations in SARS-CoV-2 genomes from Gujarat: Underlying role of variants in disease epidemiology

  (biorxiv.org)

  Published on 12th Jul 2020
• ACE2-expressing endothelial cells in aging mouse brain

  (biorxiv.org)

  Published on 12th Jul 2020
• Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

  (biorxiv.org)

  Published on 9th Jul 2020
• Single source of pangolin CoVs with a near identical Spike RBD to SARS-CoV-2

  (biorxiv.org)

  Published on 8th Jul 2020
• The major genetic risk factor for severe COVID-19 is inherited from Neandertals

  (biorxiv.org)

  Published on 5th Jul 2020
• Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

  (biorxiv.org)

  Published on 3rd Jul 2020
• Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2

  (biorxiv.org)

  Published on 2nd Jul 2020
• Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells

  (biorxiv.org)

  Published on 2nd Jul 2020
• A simple, safe and sensitive method for SARS-CoV-2 inactivation and RNA extraction for RT-qPCR

  (biorxiv.org)

  Published on 2nd Jul 2020
• If the link missed：Could inflammatory skin disorders with barrier dysfunction increase the risk of COVID-19?

  (biorxiv.org)

  Published on 2nd Jul 2020
• SARS-CoV-2 reactive T cells in uninfected individuals are likely expanded by beta-coronaviruses

  (biorxiv.org)

  Published on 2nd Jul 2020
• Citizen Scientists Create an Exascale Computer to Combat COVID-19

  (biorxiv.org)

  Published on 1st Jul 2020
• A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

  (biorxiv.org)

  Published on 1st Jul 2020
• SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

  (biorxiv.org)

  Published on 1st Jul 2020
• An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

  (biorxiv.org)

  Published on 1st Jul 2020
• Structure of the full SARS-CoV-2 RNA genome in infected cells

  (biorxiv.org)

  Published on 1st Jul 2020
• Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

  (biorxiv.org)

  Published on 1st Jul 2020
• Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor

  (biorxiv.org)

  Published on 30th Jun 2020
• Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

  (biorxiv.org)

  Published on 30th Jun 2020
• Saliva sampling is an excellent option to increase the number of SARS CoV2 diagnostic tests in settings with supplies shortages

  (biorxiv.org)

  Published on 28th Jun 2020
• Nanotrap® particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free transport medium methods

  (biorxiv.org)

  Published on 28th Jun 2020
• Modified Vaccinia Ankara Based SARS-CoV-2 Vaccine Expressing Full-Length Spike Induces Strong Neutralizing Antibody Response

  (biorxiv.org)

  Published on 28th Jun 2020
• Scalable, rapid and highly sensitive isothermal detection of SARS-CoV-2 for laboratory and home testing

  (biorxiv.org)

  Published on 25th Jun 2020
• Genetic Diversity and Genomic Epidemiology of SARS-COV-2 in Morocco

  (biorxiv.org)

  Published on 24th Jun 2020
• The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

  (biorxiv.org)

  Published on 24th Jun 2020
• Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

  (biorxiv.org)

  Published on 23rd Jun 2020
• Endemic human coronaviruses induce distinct antibody repertoires in adults and children

  (biorxiv.org)

  Published on 23rd Jun 2020
• Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

  (biorxiv.org)

  Published on 22nd Jun 2020
• Structural variability, expression profile and pharmacogenetics properties of TMPRSS2 gene as a potential target for COVID-19 therapy

  (biorxiv.org)

  Published on 22nd Jun 2020
• RNA-Dependent RNA Polymerase From SARS-CoV-2. Mechanism Of Reaction And Inhibition By Remdesivir.

  (biorxiv.org)

  Published on 22nd Jun 2020
• A path towards SARS-CoV-2 attenuation: metabolic pressure on CTP synthesis rules the virus evolution

  (biorxiv.org)

  Published on 22nd Jun 2020
• The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera

  (biorxiv.org)

  Published on 22nd Jun 2020
• Rapid Inactivation of SARS-CoV-2 by Silicon Nitride, Copper, and Aluminum Nitride

  (biorxiv.org)

  Published on 22nd Jun 2020
• High-density amplicon sequencing identifies community spread and ongoing evolution of SARS-CoV-2 in the Southern United States

  (biorxiv.org)

  Published on 21st Jun 2020
• A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

  (biorxiv.org)

  Published on 21st Jun 2020
• Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19

  (biorxiv.org)

  Published on 19th Jun 2020
• Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids

  (biorxiv.org)

  Published on 19th Jun 2020
• Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

  (biorxiv.org)

  Published on 18th Jun 2020
• Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

  (biorxiv.org)

  Published on 18th Jun 2020
• Cell entry of SARS-CoV-2 conferred by angiotensin-converting enzyme 2 (ACE2) of different specie

  (biorxiv.org)

  Published on 17th Jun 2020
• Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

  (biorxiv.org)

  Published on 17th Jun 2020
• Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19

  (biorxiv.org)

  Published on 17th Jun 2020
• Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

  (biorxiv.org)

  Published on 17th Jun 2020
• The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types

  (biorxiv.org)

  Published on 16th Jun 2020
• A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

  (biorxiv.org)

  Published on 15th Jun 2020
• Interactions of SARS-CoV-2 infection with chronic obesity inflammation: a complex network phenomenon

  (biorxiv.org)

  Published on 14th Jun 2020
• Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

  (biorxiv.org)

  Published on 14th Jun 2020
• Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

  (biorxiv.org)

  Published on 14th Jun 2020
• Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

  (biorxiv.org)

  Published on 14th Jun 2020
• Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

  (biorxiv.org)

  Published on 12th Jun 2020
• SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

  (biorxiv.org)

  Published on 12th Jun 2020
• Unravelling the debate on heme effects in COVID-19 infections

  (biorxiv.org)

  Published on 11th Jun 2020
• Stability of SARS-CoV-2 Phylogenies

  (biorxiv.org)

  Published on 11th Jun 2020
• The Distal Polybasic Cleavage Sites of SARS-CoV-2 Spike Protein Enhance Spike Protein-ACE2 Binding

  (biorxiv.org)

  Published on 11th Jun 2020
• The hypothalamus as a hub for putative SARS-CoV-2 brain infection

  (biorxiv.org)

  Published on 10th Jun 2020
• Molecular modelling predicts SARS-CoV-2 ORF8 protein and human complement Factor 1 catalytic domain sharing common binding site on complement C3b

  (biorxiv.org)

  Published on 10th Jun 2020
• D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion Assembly

  (biorxiv.org)

  Published on 10th Jun 2020